Genetics of complement C4. Two homoduplication haplotypes C4S C4S and C4F C4F in a family

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 1982 English Publisher:Springer Science and Business Media LLCJournal:Human Genetics, volume 61, pages 36-38 (issn: 0340-6717, eissn: 1432-1203,

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Authors: G, Bruun-Petersen; L U, Lamm; B K, Jacobsen; T, Kristensen;

doi: 10.1007/bf00291328

pmid: 7129423

Genetics of complement C4. Two homoduplication haplotypes C4S C4S and C4F C4F in a family

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Abstract

A family in which two homoduplicated C4 haplotypes (or supergenes) segregate is described. One haplotype C4F*3 C4F*2.2 is composed of two C4F alleles and the other C4S*5.1 C4S*1 of two C4S alleles. The C4F duplication haplotype is a partial inhibitor of the Rodgers antigen, and judged from our family and population material, it seems to be rather frequent and associated with HLAB*35, Bf*F, and HLAD/DR*1. The C4S duplication haplotype is Rg(a-) and is not identified in individuals without another S, Ch(A+) variant.

Related Organizations

Aarhus University
Denmark

Keywords

Adult, Electrophoresis, Male, Phenotype, Genes, Humans, Complement C4, Female, Child, Pedigree

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