Genetic studies of complement C4 in man
Copyright policy )Genetic studies of complement C4 in man
A C4 variant found in about 5% of the population is described. The fast-moving part of this variant is governed by an allele (Fx) codominant to F. The Fx allele is in very strong linkage disequilibrium with HLA-B17 as the linkage disequilibrium parameter accounted for nearly 100% of the haplotype frequency of B17,Fx. The strong association is also evidenced by the study of 11 families segregating for the Fx allele. There was no instance of recombination between C4 and HLA in 36 informative meioses.
- Aarhus University Denmark
Adult, Male, Genetic Linkage, Denmark, Chromosome Mapping, Genetic Variation, Complement C4, Phenotype, Gene Frequency, HLA Antigens, Humans, Female, Child, Genes, Dominant
Adult, Male, Genetic Linkage, Denmark, Chromosome Mapping, Genetic Variation, Complement C4, Phenotype, Gene Frequency, HLA Antigens, Humans, Female, Child, Genes, Dominant
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