Genotoxic effects of ketamine on CHO cells

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1986 English Publisher:Springer Science and Business Media LLCJournal:Archives of Toxicology, volume 59, pages 124-125 (issn: 0340-5761, eissn: 1432-0738,

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Authors: S G, Adhvaryu; A H, Trivedi; K H, Jani; R C, Vyas; B J, Dave;

doi: 10.1007/bf00286736

pmid: 3753193

Genotoxic effects of ketamine on CHO cells

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Abstract

Ketamine, a non-barbiturate anaesthetic agent, was studied for its genotoxic potential using the SCE assay. It was genotoxic in the in vitro system at concentrations comparable to the plasma levels achieved during steady state anaesthesia. It had no effects on cellular kinetics in CHO cells.

Related Organizations

Gujarat Cancer & Research Institute
India

Keywords

Cricetulus, Mutagenicity Tests, Cricetinae, Ovary, Animals, Female, Ketamine, Sister Chromatid Exchange, Cell Line, Mutagens

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