Cytogenetic analysis of in vitro fertilization (IVF) failures

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1989 English Publisher:Springer Science and Business Media LLCJournal:Human Genetics, volume 81, pages 367-370 (issn: 0340-6717, eissn: 1432-1203,

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Authors: M H, Pieters; J P, Geraedts; J C, Dumoulin; J L, Evers; M, Bras; F H, Kornips; P P, Menheere;

doi: 10.1007/bf00283693

pmid: 2703240

Cytogenetic analysis of in vitro fertilization (IVF) failures

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Abstract

Cytogenetic studies were carried out on 150 oocytes obtained in a human in vitro fertilization (IVF) program. Although all cells lacked signs of fertilization at light microscopy, 46 (30.7%) appeared to show cytological evidence of fertilization. At least one-third of these cells (with development arrested before first cleavage) had chromosomal aberrations. An aneuploidy rate of 35% was found in unfertilized oocytes. The results of this study explain some of the fertilization failures and of the failures of postfertilization development.

Related Organizations

Maastricht University Medical Centre
Netherlands
Transnational University Limburg
Netherlands

Keywords

Chromosome Aberrations, Polyploidy, Oocytes, Humans, Female, Fertilization in Vitro, Aneuploidy

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