A BrdU-requiring fragile site on chromosome 12
Copyright policy )A BrdU-requiring fragile site on chromosome 12
A BrdU-requiring fragile site, fra(12)(q24.2), on human chromosome 12 of some individuals is reported. This fragile site is inherited in a Mendelian codominant fashion and does not seem to be associated with any physical or mental abnormality in carriers. It was mostly observed as a chromatid gap: no acentric fragments, triradials or deleted chromosomes were found. The fra(12)(q24.2) was expressed in 34%-48% of metaphases in lymphocyte cultures from carriers when BrdU and FdU were added 6.5 h before harvest, while the expression ranged between 5% and 20% when the cultures were treated with BrdU alone. The fra(12)(q24.2) represents the second BrdU-requiring rare fragile site described on human chromosomes.
- University of Freiburg Germany
Male, Chromosomes, Human, Pair 12, Chromosome Fragile Sites, Chromosome Fragility, Infant, Chromosome Banding, Pedigree, Bromodeoxyuridine, Karyotyping, Humans, Female, Child
Male, Chromosomes, Human, Pair 12, Chromosome Fragile Sites, Chromosome Fragility, Infant, Chromosome Banding, Pedigree, Bromodeoxyuridine, Karyotyping, Humans, Female, Child
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