Complete deficiency of constitutive heterochromatin on a human chromosome 9
Copyright policy )Complete deficiency of constitutive heterochromatin on a human chromosome 9
In cultured amniotic fluid cells a mediocentric chromosome 9 appeared to be completely deficient in constitutive heterochromatin when stained with distamycin A and DAPI. In addition, this deficient chromosome was found in a blood cell culture from the father. Both the father and the child after birth were phenotypically normal. Evidently, a considerable heterozygotic deficit of chromosome 9 heterochromatin can be tolerated without affecting the phenotype. The heterochromatin defect was also shown by G11-staining. Distamycin A-DAPI staining is highly reproducible and is recommended as a fluorescent alternative to often less successful G11-methods for the detection of heteromorphism of chromosome 9.
- University of Groningen Netherlands
Adult, Chromosomes, Human, 6-12 and X, Male, Heterozygote, Staining and Labeling, Infant, Newborn, Amniotic Fluid, Phenotype, Pregnancy, Heterochromatin, Karyotyping, Humans, Female
Adult, Chromosomes, Human, 6-12 and X, Male, Heterozygote, Staining and Labeling, Infant, Newborn, Amniotic Fluid, Phenotype, Pregnancy, Heterochromatin, Karyotyping, Humans, Female
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