
doi: 10.1007/bf00275864
pmid: 6491545
Based on a stochastic pharmacokinetical model (which mirrors topological properties of the circulatory system) it is shown by reinterpreting results of Wise (1974) that if the transit times of circulating drug molecules have a generalized inverse Gaussian distribution the corresponding residence times are gamma distributed. The condition that the probability of elimination of a drug molecule in a single circulatory passage is sufficiently small appears to be valid for most drugs. Thus theoretical evidence is given for fitting blood concentration-time curves following bolus injection of a single dose by power functions of time.
recirculatory model, gamma distribution, Statistics as Topic, Physiological, cellular and medical topics, renewal density, residence times, Models, Biological, fitting blood concentration-time curves, generalized inverse Gaussian distribution, Kinetics, vascular fluid, Pharmaceutical Preparations, circulating drug molecules, Humans, transit times, System identification
recirculatory model, gamma distribution, Statistics as Topic, Physiological, cellular and medical topics, renewal density, residence times, Models, Biological, fitting blood concentration-time curves, generalized inverse Gaussian distribution, Kinetics, vascular fluid, Pharmaceutical Preparations, circulating drug molecules, Humans, transit times, System identification
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