Aggregation of cell surface receptors by multivalent ligands
Copyright policy )Aggregation of cell surface receptors by multivalent ligands
Using a combination of branching processes and kinetic equations a solution is provided to the problem of describing the size of aggregates formed on cell surfaces when multivalent ligands bind and cross-link multivalent receptors. A criterion is given for the onset of gelation in infinite 2-dimensional systems, which may be relevant to the phenomenon of ligand-induced receptor patching.
- Los Alamos National Laboratory United States
multivalent ligands, Macromolecular Substances, Receptors, Drug, Cell Membrane, Physiological, cellular and medical topics, kinetic equations, Ligands, antigen-antibody reactions, Models, Biological, Kinetics, Applications of branching processes, Animals, aggregation of cell surface receptors, General biology and biomathematics, receptor clustering, Mathematics
multivalent ligands, Macromolecular Substances, Receptors, Drug, Cell Membrane, Physiological, cellular and medical topics, kinetic equations, Ligands, antigen-antibody reactions, Models, Biological, Kinetics, Applications of branching processes, Animals, aggregation of cell surface receptors, General biology and biomathematics, receptor clustering, Mathematics
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