
doi: 10.1007/bf00270295
pmid: 4453105
This paper describes a model for the generation of repetitive firing patterns in single neurons to be used as a module in large-scale network simulation studies. The model is based on the combination of extended versions of Hill's model for accomodation and of Kernell's model for adaptation. Both digital computer and electronic circuit realizations of the model are presented. The model is shown to produce strength-duration curves for accomodation which are compatible with available data from real neurons. Both “high ceiling” and “low ceiling” cell types can be matched by adjusting parameters in the model. An equation relating steady-state firing rate to amplitude of applied steady current is presented which includes the accumulation of potassium conductance changes with repetitive firing. The occurence of phasic and tonic responses to step stimulation is mapped in the parameter space of the model. Several representative response patterns to irregular inputs are presented.
Neurons, Computers, Switching theory, application of Boolean algebra; Boolean functions, Models, Neurological, Synapses, Neural Conduction, Electronics, General biology and biomathematics, Mathematics, Membrane Potentials
Neurons, Computers, Switching theory, application of Boolean algebra; Boolean functions, Models, Neurological, Synapses, Neural Conduction, Electronics, General biology and biomathematics, Mathematics, Membrane Potentials
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