Modulation of RNA polymerase specificity by ppGpp

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1976 English Publisher:Springer Science and Business Media LLCJournal:Molecular and General Genetics MGG, volume 147, pages 225-232 (issn: 0026-8925, eissn: 1432-1874,

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Authors: A, Travers;

doi: 10.1007/bf00267575

pmid: 787760

Modulation of RNA polymerase specificity by ppGpp

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Abstract

ppGpp alters the initiation specificity of RNA polymerase holoenzyme in vitro in a direction which mimics the stringent response in vivo. The transition temperature for opening rRNA promoters is increased by the nucleotide, that for opening phi80 promoters is unaffected. This implies that RNA polymerase can discriminate between different types of promoter. ppGpp may act by effecting a structural change in the enzyme.

Related Organizations

Medical Research Council
United Kingdom
MRC Laboratory of Molecular Biology
United Kingdom

Keywords

RNA, Bacterial, Transcription, Genetic, RNA, Ribosomal, DNA, Viral, Escherichia coli, RNA, Viral, Coliphages, Guanine Nucleotides

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