Mutagenesis and mutant selection in Physarum polycephalum

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1972 English Publisher:Springer Science and Business Media LLCJournal:Molecular and General Genetics MGG, volume 118, pages 109-124 (issn: 0026-8925, eissn: 1432-1874,

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Authors: F B, Haugli; W F, Dove;

doi: 10.1007/bf00267082

pmid: 4673170

Mutagenesis and mutant selection in Physarum polycephalum

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Abstract

Physarum polycephalum myxamoebae were exposed to ultraviolet irradiation and plated in the absence and presence of caffeine. Caffeine reduces the shoulder on the UV1 dose-survival curve, thereby increasing the UV-sensitivity for survival. Caffeine alone is a moderate mutagen. Used in conjunction with UV a strong mutagenic action is observed. Active growth is required for both of these mutagenic actions.

Related Organizations

University of Wisconsin–Madison
United States
University of Wisconsin Hospital and Clinics
United States
UW Carbone Cancer Center
United States

Keywords

Genetics, Microbial, Ultraviolet Rays, Caffeine, Mutation, Temperature, Radiation Genetics, Myxomycetes, Mutagens, Nitrosoguanidines

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