Comparative bioavailability of diclofenac hydroxyethylpyrrolidine vs diclofenac sodium in man
Copyright policy )Comparative bioavailability of diclofenac hydroxyethylpyrrolidine vs diclofenac sodium in man
A phamacokinetic study in man has been made of a new dosage form of diclofenac hydroxyethylpyrrolidine (DIEP); soluble salt packed in sachets was compared with diclofenac sodium as enteric coated tablets. Oral DIEP 2 X 50 mg showed a significant difference in absorption kinetics (ka, lag time and tmax) as compared to oral diclofenac sodium 2 X 50 mg. A relevant plasma concentration of diclofenac was detected just 15 min after DIEP, while diclofenac sodium produced a measurable plasma concentration only 0.5-1 h after the treatment. Cmax and t1/2 after DIEP and diclofenac sodium were comparable. Comparison of the two AUC values showed that DIEP was bioequivalent to diclofenac sodium (Q = 100%).
Male, Diclofenac, Biological Availability, Humans, Female, Middle Aged
Male, Diclofenac, Biological Availability, Humans, Female, Middle Aged
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