descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1992 English Publisher:Springer Science and Business Media LLCJournal:European Journal of Clinical Pharmacology, volume 42 (issn: 0031-6970, eissn: 1432-1041,

Authors: Michael D. Rawlins; Robert Woestenborghs; L. Adriaens; M. L. Huang; Farhad Kamali; M. Emanuel;

doi: 10.1007/bf00265940

pmid: 1623916

Dose proportionality study of loperamide following oral administration of loperamide oxide

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Abstract

The pharmacokinetics of loperamide, after oral administration of increasing doses (1 to 16 mg) of loperamide oxide, has been investigated in 10 healthy male volunteers, using a randomised cross-over design. Comparison of the maximum plasma loperamide concentration and AUC demonstrated that the bioavailability of loperamide was proportional to the dose of loperamide oxide administered.

Related Organizations

Newcastle University
United Kingdom
Johnson & Johnson (United States)
United States
Janssen (Belgium)
Belgium
Janssen Pharmaceutica
Belgium

Keywords

Adult, Male, Analysis of Variance, Dose-Response Relationship, Drug, Double-Blind Method, Administration, Oral, Biological Availability, Humans, Loperamide, Biotransformation

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