Dose-dependent pharmacokinetics of PMM in the rat

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1981 English Publisher:Springer Science and Business Media LLCJournal:Cancer Chemotherapy and Pharmacology, volume 5, pages 201-203 (issn: 0344-5704, eissn: 1432-0843,

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Authors: T, Colombo; L, Torti; M, D'Incalci;

doi: 10.1007/bf00258481

pmid: 6794923

Dose-dependent pharmacokinetics of PMM in the rat

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Abstract

Concentrations of pentamethylmelamine (PMM) and some metabolites were determined in plasma of rats treated with 10 and 50 mg PMM/kg IV. The areas under the plasma levels curve after these doses were 241 and 1,827 mu g/ml X min; plasma clearances were 0.042 and 0.027 l . kg(-1) . min(-1), respectively. These data suggest that PMM pharmacokinetics is dose-dependent in the rat. The N-demethylated metabolite levels were not proportional to the administered dose.

Related Organizations

Mario Negri Institute for Pharmacological Research
Italy

Keywords

Male, Kinetics, Triazines, Animals, Altretamine, Biotransformation, Rats

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