Chemotherapeutic agents do not interact with neurotransmitter receptors
Copyright policy )Chemotherapeutic agents do not interact with neurotransmitter receptors
The interactions of cisplatin, 5-fluorouracil, doxorubicin, mitomycin, carmustine (BCNU), cyclophosphamide, methotrexate and thio-TEPA were assessed at three neurotransmitter receptor binding sites. Each drug was inactive at concentrations as high as 10(-4) M in displacing the specific binding of 3H-spiperone to dopamine D2, 3H-pyrilamine to histamine H1, and 3H-quinuclidinyl benzilate to muscarinic cholinergic receptors. These data suggest that chemotherapy-induced nausea and vomiting are not due to interactions with neurotransmitter receptors.
- Stanford Medicine United States
- Stanford University United States
Animals, Brain, Receptors, Histamine, Antineoplastic Agents, Nausea, Receptors, Histamine H1, Binding, Competitive, Receptors, Muscarinic, Rats, Receptors, Dopamine
Animals, Brain, Receptors, Histamine, Antineoplastic Agents, Nausea, Receptors, Histamine H1, Binding, Competitive, Receptors, Muscarinic, Rats, Receptors, Dopamine
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