Identification of three neurofibromatosis type 2 (NF2) gene mutations in vestibular schwannomas
Copyright policy )Identification of three neurofibromatosis type 2 (NF2) gene mutations in vestibular schwannomas
Vestibular schwannomas (VSs) are common benign tumors of Schwann cell origin and are frequently found in patients with neurofibromatosis type 2 (NF2). We analyzed 15 sporadic VSs for mutations in the tumors, two of which contained loss of heterozygosity (LOH). One of the tumors contained a novel mutation, a 19-bp deletion in exon 4. The two other tumors contained an identical mutation, a complete exon 4 deletion. The exon 4 deletion represents the second most frequently reported mutation of the NF2 gene in VSs.
- Cedars-Sinai Medical Center United States
- University of California, Los Angeles United States
Transcription, Genetic, Exons, Polymerase Chain Reaction, Genes, Neurofibromatosis 2, Mutation, Humans, Vestibule, Labyrinth, Chromosome Deletion, Ear Neoplasms, Neurilemmoma, Sequence Deletion
Transcription, Genetic, Exons, Polymerase Chain Reaction, Genes, Neurofibromatosis 2, Mutation, Humans, Vestibule, Labyrinth, Chromosome Deletion, Ear Neoplasms, Neurilemmoma, Sequence Deletion
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).9 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!