Haplotypic polymorphisms of the TNFB gene
Copyright policy )Haplotypic polymorphisms of the TNFB gene
The TNFB genes from two major histocompatibility complex (MHC) ancestral haplotypes have been compared. The genes carried by the ancestral haplotypes 8.1 (A1,B8,BfS,C4AQ0, C4B1,DR3) and 57.1 (A1, B57. BfS, C4A6, C4B1, DR7) were cloned and sequenced to determine the degree of polymorphism. In this report we show that the respective TNF genes are allelic and have unique nucleotide sequences. The data demonstrate the presence of three nucleotide differences between the TNFB alleles of 8.1 and 57.1. Two of the differences occur in untranslated regions of the gene but the third nucleotide change results in an amino acid difference in the mature TNFB protein. These polymorphisms may have implications with respect to differential regulation in disease- and nondisease-associated haplotypes.
- Harvard University United States
- Royal Perth Hospital Australia
Base Sequence, Tumor Necrosis Factor-alpha, Molecular Sequence Data, Major Histocompatibility Complex, Haplotypes, Sequence Homology, Nucleic Acid, Humans, Cloning, Molecular, Lymphotoxin-alpha, Alleles, Polymorphism, Restriction Fragment Length, Gene Library
Base Sequence, Tumor Necrosis Factor-alpha, Molecular Sequence Data, Major Histocompatibility Complex, Haplotypes, Sequence Homology, Nucleic Acid, Humans, Cloning, Molecular, Lymphotoxin-alpha, Alleles, Polymorphism, Restriction Fragment Length, Gene Library
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