Mobility of uranium with ground water in near surface earth conditions and its association with sandstone formations of continental depositional environments require an increase in the understanding and application of depositional characteristics in exploration. This paper, therefore, summarizes significant relationships of uranium geochemistry in the supergene environments and depositional characteristics of fluvial, deltaic, and lacustrine environments and their influence on exploration that may aid in the expeditious search for sandstone-type uranium deposits throughout the world.