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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Bulletin of Environm...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Bulletin of Environmental Contamination and Toxicology
Article . 1994 . Peer-reviewed
License: Springer TDM
Data sources: Crossref
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Effect of the bioflavonoid morin on HEp-2 cells

Authors: A L, Pond; J M, Zamora; M R, Wells;

Effect of the bioflavonoid morin on HEp-2 cells

Abstract

Bioflavonoids are plant compounds which aid in disease resistance (MariniBettolo and Monache 1977) and attract pollinating insects (Thompson et al. 1972). Flavonoids have been shown to affect biological systems variably, having antibacterial, antiviral (Miski et al. 1983), antifungal (Donnelly 1977), mutagenic (Brown 1980), antineoplastic and/or enzyme inhibitory properties (Pritsos et al. 1985; Bohmont et al. 1987; Hodnick et al. 1986; Duval et al. 1988). Antibacterial activity against Mycobacterium phlei was demonstrated in five 5,6,7-trisubstituted falvones which were extracted from Gompherena rnartiana and G. boliviana (Pomilio et al 1992). The flavonoid cirsimaritin, which was extracted from the leaves of Salvia palaestina, was demonstrated to have high activity against Staphylococcus aureus, S. epidermitis, Echerichia coli, Klebsiella pneumoniae, Proteus vulgaris and Pseudomonas aeruginosa (Miski et al. 1983). Antiviral activity was discovered in baicalin, a flavonoid extracted form Seutellaria baicalensis georgi, which inhibited human T and B cells via inhibition of the reverse transcriptase of infected ceils (Baylor et al. 1992). Further, flavonoid inhibition of reverse transcriptase activity in Moloney murine leukemia infected cells has been reported (Chu et al. 1992). For example, a number of flavonoids were shown to inhibit the activity of succinoxidase (Hodnick et al. 1986) and other flavonoids have been reported to inhibit mitochondrial respiration via inhibition of NADH oxidase, succinoxidase and ATPase (Bohmont et al. 1987). Mitochondrial enzymes are not the only enzymes affected by flavonoids. The flavonoid dichlone interferes with liver glycolysis in rats via inhibition of glutathione reductase (Pristos et al. 1985). Antineoplastic activity has been demonstrated in the cytotoxic flavonoid eupatorin which displayed cytotoxic activity against human carcinoma of the nasopharynx (Kupchan et al. 1979). Three flavonoids with inhibitory activities against Epstein-Barr virus early antigen induction by a tumor promoter have been isolated (Murakami 1992). Further, twelve flavonoids which inhibited antineoplastic activity against adenocarcinoma 755, Friend virus leukemia, Lewis lung carcinoma and Walker carcinosarcoma 256 have been reported (Edwards et al 1979).

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Keywords

Flavonoids, Male, Cell Survival, Cell Count, Middle Aged, Flavones, Antioxidants, Electron Transport Complex IV, Carcinoma, Squamous Cell, Tumor Cells, Cultured, Humans, Indicators and Reagents, Laryngeal Neoplasms, Cell Division, HeLa Cells

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
3
Average
Average
Average
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