Trophoblast glycoprotein recognised by monoclonal antibody 5T4 maps to human chromosome 6q14?q15

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1990 English Publisher:Springer Science and Business Media LLCJournal:Human Genetics, volume 84 (issn: 0340-6717, eissn: 1432-1203,

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Authors: J M, Boyle; K H, Grzeschik; P R, Heath; J E, Morten; P L, Stern;

doi: 10.1007/bf00195819

pmid: 2323778

Trophoblast glycoprotein recognised by monoclonal antibody 5T4 maps to human chromosome 6q14?q15

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Abstract

Human X rodent hybrids were stained by indirect immunofluorescence with 5T4, a murine monoclonal antibody that recognises a 72 kdalton glycoprotein expressed by human trophoblasts and a very restricted range of adult tissues; they were analysed by flow cytometry. Concordance analysis supported by segregation data allowed assignment of the gene controlling glycoprotein expression (M6P1) to chromosome 6. Similar analysis with translocation hybrids gave a regional assignment to 6q14-q15. M6P1 is distinct from NT5, coding for 5' nucleotidase, which maps to the same region.

Related Organizations

Cancer Research UK Manchester Institute
United Kingdom
The Christie Hospital
United Kingdom
Christie Hospital NHS Foundation Trust
United Kingdom
Philipps-University of Marburg
Germany

Keywords

Genetic Markers, Membrane Glycoproteins, Antibodies, Monoclonal, Hybrid Cells, Pregnancy Proteins, Chromosome Banding, Trophoblasts, Cricetulus, Pregnancy, Cricetinae, Animals, Humans, Chromosomes, Human, Pair 6, Female, Biomarkers

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