Recombinant epidermolytic (exfoliative) toxin A of Staphylococcus aureus is not a superantigen
Copyright policy )Recombinant epidermolytic (exfoliative) toxin A of Staphylococcus aureus is not a superantigen
The epidermolytic (exfoliative) toxins produced by Staphylococcus aureus cause epidermolysis and skin blistering. In addition, they have been implicated to belong to the group of T lymphocyte stimulating molecules known as "superantigens". Here we show that recombinant epidermolytic toxin A produced in S. aureus is not mitogenic for human and murine T lymphocytes. We discuss the possibility that minute contaminations of highly mitogenic exoproteins may cause the mitogenicity in several proteins that are reported to be superantigens.
- Johannes Gutenberg University of Mainz Germany
- University College Dublin Ireland
- Trinity College Dublin Ireland
Antigens, Bacterial, Mice, Inbred BALB C, Staphylococcus aureus, T-Lymphocytes, Blotting, Western, Lymphocyte Activation, Monocytes, Recombinant Proteins, Exfoliatins, Mice, Animals, Humans, Interleukin-2, Cloning, Molecular, Cells, Cultured, Spleen
Antigens, Bacterial, Mice, Inbred BALB C, Staphylococcus aureus, T-Lymphocytes, Blotting, Western, Lymphocyte Activation, Monocytes, Recombinant Proteins, Exfoliatins, Mice, Animals, Humans, Interleukin-2, Cloning, Molecular, Cells, Cultured, Spleen
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