
doi: 10.1007/bf00186381
pmid: 8393429
Between June 1985 and May 1990 we treated 12 patients with malignant fibrous histiocytoma (MFH) of the limbs by a combination of wide excision and adjuvant radiotherapy. The Enneking surgical staging was II in 11 cases and III in 1. There were 6 women and 6 men, with an average age of 54 years. The leg was involved in 8 patients and the arm in 4. Limb salvage was achieved in 10 patients and amputation was performed in 2. All received adjuvant radiotherapy, with an average of 51.5 Gy. In 6 patients adjuvant CYVADIC chemotherapy was administered for an average of 4 cycles. In the other patients this treatment was not tolerated. Local recurrence occurred in 2 patients and metastases to the lung were seen in a further 2. At an average follow-up of 41.3 months, the Kaplan-Meier estimation of 5 year survival was 87.5%, with a 5 year continuous disease-free survival rate of 66.7%.
Adult, Male, Leg, Histiocytoma, Benign Fibrous, Radiotherapy Dosage, Soft Tissue Neoplasms, Middle Aged, Prognosis, Combined Modality Therapy, Dacarbazine, Doxorubicin, Vincristine, Antineoplastic Combined Chemotherapy Protocols, Arm, Humans, Female, Cyclophosphamide, Aged
Adult, Male, Leg, Histiocytoma, Benign Fibrous, Radiotherapy Dosage, Soft Tissue Neoplasms, Middle Aged, Prognosis, Combined Modality Therapy, Dacarbazine, Doxorubicin, Vincristine, Antineoplastic Combined Chemotherapy Protocols, Arm, Humans, Female, Cyclophosphamide, Aged
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