Production of desferrioxamine E and new analogues by directed fermentation and feeding fermentation

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1990 English Publisher:Springer Science and Business Media LLCJournal:Applied Microbiology and Biotechnology, volume 32 (issn: 0175-7598, eissn: 1432-0614,

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Authors: J, Meiwes; H P, Fiedler; H, Zähner; S, Konetschny-Rapp; G, Jung;

doi: 10.1007/bf00173718

pmid: 1367428

Production of desferrioxamine E and new analogues by directed fermentation and feeding fermentation

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Abstract

Streptomyces olivaceus TU 2718 produces the siderophore desferrioxamine E. Production depends on L-lysine and iron concentrations in the medium. With optimized conditions the yield of desferrioxamine E could be increased to 12 g/l in feeding fermentations. Supplementation of the basic production medium with natural and synthetic precursors of desferrioxamine E led to the production of twelve new analogues of desferrioxamine E.

Related Organizations

University of Tübingen
Germany

Keywords

Bacteriological Techniques, Sucrose, Iron, Lysine, Fermentation, Deferoxamine, Hydrogen-Ion Concentration, Chromatography, High Pressure Liquid, Streptomyces, Culture Media

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