Comparative analysis of Homo sapiens and Mus musculus cyclin-dependent kinase (CDK) inhibitor genes P16 (MTS1) and P15 (MTS2)
Copyright policy )Comparative analysis of Homo sapiens and Mus musculus cyclin-dependent kinase (CDK) inhibitor genes P16 (MTS1) and P15 (MTS2)
Cyclin-dependent kinase inhibitors are a growing family of molecules that regulate important transitions in the cell cycle. At least one of these molecules, p16, has been implicated in human tumorigenesis while its close homolog, p15, is induced by cell contact and transforming growth factor-beta (TGF-beta). To investigate the evolutionary and functional features of p15 and p16, we have isolated mouse (Mus musculus) homologs of each gene. Comparative analysis of these sequences provides evidence that the genes have similar functions in mouse and human. In addition, the comparison suggests that a gene conversion event is part of the evolution of the human p15 and p16 genes.
- Myriad Genetics (Germany) Germany
- National Institute of Allergy and Infectious Diseases United States
- California Institute of Technology United States
- National Institutes of Health United States
Base Sequence, Tumor Suppressor Proteins, Molecular Sequence Data, Cell Cycle Proteins, Hominidae, Evolution, Molecular, Mice, Animals, Humans, Amino Acid Sequence, Enzyme Inhibitors, Carrier Proteins, Protein Kinase Inhibitors, Sequence Alignment, Sequence Analysis, Conserved Sequence, Cyclin-Dependent Kinase Inhibitor p16, Cyclin-Dependent Kinase Inhibitor p15
Base Sequence, Tumor Suppressor Proteins, Molecular Sequence Data, Cell Cycle Proteins, Hominidae, Evolution, Molecular, Mice, Animals, Humans, Amino Acid Sequence, Enzyme Inhibitors, Carrier Proteins, Protein Kinase Inhibitors, Sequence Alignment, Sequence Analysis, Conserved Sequence, Cyclin-Dependent Kinase Inhibitor p16, Cyclin-Dependent Kinase Inhibitor p15
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).20 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!