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Detection of viral antigen in the endolymphatic sac

Name: Detection of viral antigen in the endolymphatic sac
Creator: Hidehaku Kumagami
Keywords: Male, Herpesvirus 2, Human, Infant, Newborn, Cytomegalovirus, Infant, Herpes Simplex, Herpesvirus 1, Human, Middle Aged, 3. Good health, Immunoenzyme Techniques

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1996Publisher:Springer Science and Business Media LLCJournal:Oto-Rhino-Laryngology, volume 253 (issn: 0937-4477, eissn: 1434-4726,

Authors: Hidehaku Kumagami;

doi: 10.1007/bf00171140

pmid: 8737782

Detection of viral antigen in the endolymphatic sac

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Abstract

A study was devised to determine whether or not any immune defense mechanism is present when a virus invades the human endolymphatic sac (ES). The ES was removed from 14 fresh autopsy cases having no known pre-mortem diseases in the middle and inner ears. Specimens were then examined for viral antigens including herpes simplex (HSV) type 1 and 2, mumps and cytomegalovirus using immunohistochemical methods. DNA examination by in situ hybridization was also performed for HSV. HSV antigen and DNA were observed in 9 of the 14 cases studied. These findings suggest that the virus invades the ES but is impeded by an immune defense mechanism under normal conditions. Since disease may alter host defenses, further studies are warranted to study the relationship between HSV and patients with Meniere's disease.

Related Organizations

Nagasaki University
Japan

Keywords

Male, Herpesvirus 2, Human, Infant, Newborn, Cytomegalovirus, Infant, Herpes Simplex, Herpesvirus 1, Human, Middle Aged, Immunoenzyme Techniques, Mumps virus, Humans, Female, Endolymphatic Sac, Antigens, Viral, Meniere Disease, Aged

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	17
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average