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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Applied Microbiology...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Applied Microbiology and Biotechnology
Article . 1993 . Peer-reviewed
License: Springer TDM
Data sources: Crossref
Applied Microbiology and Biotechnology
Article . 1994
Data sources: Europe PubMed Central
Applied Microbiology and Biotechnology
Article
Data sources: Microsoft Academic Graph
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Microbial metabolism of the \-adrenoreceptor antagonist bisoprolol

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 1993 English Publisher:Springer Science and Business Media LLCJournal:Applied Microbiology and Biotechnology, volume 40 (issn: 0175-7598, eissn: 1432-0614, Copyright policy )
Authors: Hans-Eckart Radunz; Ralf-Erwin Licht; Schwartz Harry;

doi: 10.1007/bf00170397

pmid: 7764395

Microbial metabolism of the \-adrenoreceptor antagonist bisoprolol

Abstract

Eighteen filamentous fungi and six actinomycetes species were screened for their ability to metabolize bisoprolol, a beta-blocking drug. All strains of Cunninghamella tested accumulated metabolite M4 = EMD 46193 ([4-(2-hydroxy-3-isopropylaminopropoxy)benzyloxy]ethanol). Among the strains investigated only Gliocladium deliquescens excreted the corresponding carbonic acid M1 = EMD 44025 into the culture medium. Biotransformation of bisoprolol by fungi occurred only during growth in complex medium or with resting cells after cultivation in complex medium. The screened Actinomycetes showed no biotransformation of the drug.

Related Organizations
Keywords

Fungi, Bisoprolol, Biotransformation, Chromatography, High Pressure Liquid

  • BIP!
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    citations
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    		 14
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
14
Average
Average
Average
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