Coxsackievirus B3 myocarditis in C3H/HeJ mice: Description of an inbred model and the effect of exercise on virulence
Copyright policy )Coxsackievirus B3 myocarditis in C3H/HeJ mice: Description of an inbred model and the effect of exercise on virulence
The effect of forced exercise on the development of coxsackievirus B3 myocarditis in inbred C3H/HeJ mice was studied. Four groups of mice (30 per group) were formed: infected-exercised (Group I); infected-unexercised (Group II); uninfected-exercised (Group III); and uninfected-unexercised (Group IV). Infected mice were inoculated intraperitoneally with 1.0 x 10(2.1) TCID50 coxsackievirus B3. Exercised animals were swum daily for 60 minutes on days 1-9. Myocardial viral titers were acutely elevated on day 3 of infection and were augmented significantly by exercise on days 6 and 9. Exercise increased the overall mortality from 0-10% to 20-40%; significantly increased heart: body weight ratios on days 6, 9 and 13; and increased the extent of myocardial fiber necrosis. We have reproduced the acceleration of CB3 myocarditis by exercise in the inbred C3H model.
- Wayne State University United States
- Wayne State College United States
Male, Mice, Inbred C3H, Virulence, Myocardium, Body Weight, Physical Exertion, Coxsackievirus Infections, Organ Size, Enterovirus B, Human, Disease Models, Animal, Mice, Myocarditis, Animals, Swimming
Male, Mice, Inbred C3H, Virulence, Myocardium, Body Weight, Physical Exertion, Coxsackievirus Infections, Organ Size, Enterovirus B, Human, Disease Models, Animal, Mice, Myocarditis, Animals, Swimming
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