Wavelets and molecular structure
Copyright policy )Wavelets and molecular structure
The wavelet method offers possibilities for display, editing, and topological comparison of proteins at a user-specified level of detail. Wavelets are a mathematical tool that first found application in signal processing. The multiresolution analysis of a signal via wavelets provides a hierarchical series of "best' lower-resolution approximations. B-spline ribbons model the protein fold, with one control point per residue. Wavelet analysis sets limits on the information required to define the winding of the backbone through space, suggesting a recognizable fold is generated from a number of points equal to 1/4 or less the number of residues. Wavelets applied to surfaces and volumes show promise in structure-based drug design.
- University of Alabama at Birmingham United States
Models, Molecular, Protein Folding, Molecular Structure, Protein Conformation, Drug Design, Computer-Aided Design, Humans, Signal Processing, Computer-Assisted, Mathematics
Models, Molecular, Protein Folding, Molecular Structure, Protein Conformation, Drug Design, Computer-Aided Design, Humans, Signal Processing, Computer-Assisted, Mathematics
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