In this paper, mixed-mode fracture is investigated experimentally. In the first part, critical conditions for initiation of crack growth are explored. The method of caustics was used in conjunction with a high speed video system to determine critical stress intensity factors at initiation of crack growth. It was found that the maximum tangential stress criterion originally proposed by Erdogan and Sih [1] was the best criterion in terms of predictive capability. Polymethylmethacrylate and Homalite-100 were used in the experiments and Homalite-100 was found to exhibit significant rate dependence. In the second part, crack growth initiated under mixed-mode loading is addressed. It is shown that subsequent slow crack growth in PMMA is under pure mode-I conditions.