HCG is a hormone unique to gestation, however, it may be raised in other pathological conditions as well. Human chorionic gonadotropin (hCG) is a placental hormone secreted after implantation and is commonly detected by urine gravindex test. It interacts with the LHCG receptor of the ovary and maintains the corpus luteum during initial weeks of pregnancy. It is also produced by most of the trophoblastic tumors where the serial quantitative detection with rise and fall, gives information about the course of the disease, prognosis, treatment, treatment response, and recurrence. Various levels of rise are observed in gestational trophoblastic disease and very very high level in its malignant counterpart Gestational Trophoblastic Neoplasia, including Choriocarcinoma. It is secreted mainly by the syncytiotrophoblasts soon after implantation, though also secreted in small amounts by the anterior pituitary. hCG is solely responsible for maintaining pregnancy before progesterone takes over at 12 weeks of gestation. There are various different forms of hCG that have been identified, although the function of each type is yet to be defined. It is imperative that whatever information is available be utilized for the accurate characterization of hCG-associated lesions [1].