The strong interaction between an antikaon and a nucleon is at the origin of various interesting phenomena in kaon-nuclear systems. In particular, the interaction in the isospin $I=0$ channel is sufficiently attractive to generate a quasi-bound state, the $��(1405)$ resonance, below the $\bar{K}N$ threshold. Based on this picture, it may be expected that the $\bar{K}N$ interaction also generates quasi-bound states in kaon-nuclear systems, sometimes called kaonic nuclei. At the same time, the $\bar{K}N$ quasi-bound picture of the $��(1405)$ is also related to the discussion of hadronic molecules in hadron spectroscopy. Here an overview is presented of the theoretical studies developed for kaon-nucleon and kaon-nuclear systems. We start from the modern understanding of the $��(1405)$ resonance. We then discuss the $\bar{K}N$ interaction and various aspects of few-body kaonic nuclei. Heavier kaon-nuclear systems are examined from the viewpoint of nuclear many-body physics, with focus on the properties of antikaons in nuclear matter. Related topics, such as the $K^{-}p$ momentum correlation functions in high-energy collisions and the studies of kaonic atoms, are also discussed.

32 pages, 16 figures, Contribution to the "Handbook of Nuclear Physics", Springer, 2022, edited by I. Tanihata, H. Toki and T. Kajino