Aquaporins in Urinary System
Aquaporins in Urinary System
Several aquaporin (AQP )-type water channels are expressed in kidney: AQP1 in the proximal tubule, thin descending limb of Henle, and vasa recta; AQP2 -6 in the collecting duct; AQP7 in the proximal tubule; AQP8 in the proximal tubule and collecting duct; and AQP11 in the endoplasmic reticulum of proximal tubule cells. AQP2 is the vasopressin-regulated water channel that is important in hereditary and acquired diseases affecting urine-concentrating ability. The roles of AQPs in renal physiology and transepithelial water transport have been determined using AQP knockout mouse models. This chapter describes renal physiologic insights revealed by phenotypic analysis of AQP knockout mice and the prospects for further basic and clinical studies.
- Peking University China (People's Republic of)
- State Key Laboratory of Natural and Biomimetic Drugs China (People's Republic of)
- Peking University China (People's Republic of)
Mice, Knockout, Aquaporin 1, Polyuria, Osmolar Concentration, Water, Biological Transport, Water-Electrolyte Balance, Kidney, Kidney Concentrating Ability, Mice, Gene Expression Regulation, Animals, Humans, Protein Isoforms, Urea
Mice, Knockout, Aquaporin 1, Polyuria, Osmolar Concentration, Water, Biological Transport, Water-Electrolyte Balance, Kidney, Kidney Concentrating Ability, Mice, Gene Expression Regulation, Animals, Humans, Protein Isoforms, Urea
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