The skin, as the largest organ of the body, has numerous protective roles to play throughout the span of our lives. In due course it is subject to the effects of both intrinsic (innate) and extrinsic (photo) aging. Therefore, the purpose of this chapter is to consider how the skin ages, examining the effects of aging on the organ and how this relates to changes in its function. Finally, consideration will be made of some of the many potential treatments and therapies which are currently available and which future approaches may be beneficial to ameliorate or even reverse the effects of aging.