Numerous and diverse clinical entities are associated with iris neovascularization, but the most frequently encountered are diabetes mellitus and central retinal vein occlusion. The prevalence of iris neovascularization is between 1–10% among all diabetic patients and over 40% in patients with proliferative retinopathy (1–3). The incidence of iris neovascularization among patients with central retinal vein occlusion is about 15% (4), but is only 1 to 2% in patients with central retinal artery occlusion (5). The clinical presentation, histologic pathology, and theories of pathogenesis of this disorder have been reviewed (6–14).