Conversion of Rat Xanthine Dehydrogenase to Xanthine Oxidase during Oxidative Stress

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Other literature type , Conference object 01 Jan 1988 Italy English Publisher:Springer Netherlands

Authors: BINDOLI, ALBERTO; CAVALLINI, LUCIA; RIGOBELLO, MARIA PIA; M. COASSIN; DI LISA, FABIO;

doi: 10.1007/978-94-009-2697-4_6

handle: 11577/2524705

Conversion of Rat Xanthine Dehydrogenase to Xanthine Oxidase during Oxidative Stress

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Abstract

The enzyme “xanthine oxidase” is one of the best characterized sources of superoxide anion and hydrogen peroxide. “In vivo” it mainly acts as a dehydrogenase which, by reducing NAD+, appears to be the physiologic form. Nevertheless under a variety of conditions the enzyme can undergo a conversion to an oxidase which delivers the electrons to oxygen to form superoxide and hydrogen peroxide. The transformation xanthine dehydrogenase→xanthine oxidase is irreversible when it is induced by a proteolytic attack or reversible when the SH groups of the enzyme have been oxidized.

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Italy

Related Organizations

University of Padua
Italy

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