
Conducting system potentials were first recovered from the body surface in dogs in 1973 using a sequence of high-gain amplification and filtering followed by digital signal averaging. Subsequent application of similar methods to man by more than 18 research groups world-wide have shown it feasible to record His Purkinje signals non-invasively in about 75% of subjects studied. Surface signals are of the order of 0.5-2.0 µV in amplitude. In 70-100% of cases they correlate well in time with the simultaneous internal His bundle electrogram but the pattern of surface signals varies from patient to patient. Their appearance fails to correlate with any specific underlying pathological change in AV conduction and is affected both by lead position and as a result of filtering. “High resolution” recordings made without signal averaging have been achieved in a few centres but with greater technical difficulty and a lower rate of signal recovery.
| selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 0 | |
| popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Average | |
| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Average | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Average |
