The assumption of Galactic Interstellar Dust properties in modeling the effects of Extragalactic Interstellar Dust will lead to large errors. Properties of Galactic dust have been amenable to study through observations of scattering and absorption along individual sightlines toward point sources, and through high spatial resolution observations of extended sources. Observations of Interstellar Dust in other galaxies are much more difficult since the light detected in a given aperture is the sum of a complex geometry of sources and dust which can only be separated using Radiative Transfer models. With the aid of NASA observatories such as Hubble Space Telescope (HST) and Astro-2, Interstellar Dust in Local Group galaxies can be subjected to the same kind of observations used to study Galactic dust. Individual sightlines can be observed at high spatial resolution allowing simple geometries to be studied.