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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao https://doi.org/10.1...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
https://doi.org/10.1007/978-4-...
Part of book or chapter of book . 2016 . Peer-reviewed
License: Springer TDM
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Mechanism of Homologous Recombination

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Other literature type 01 Jan 2016Publisher:Springer Japan
Authors: Marek Sebesta; Lumir Krejci;

doi: 10.1007/978-4-431-55873-6_4

Mechanism of Homologous Recombination

Abstract

Homologous recombination (HR) maintains genome stability by repairing DNA double-strand breaks and gaps and restarting replication forks. It is an error-free pathway that uses a homologous sequence in the genome to copy the damaged genetic information. In the present chapter, we will discuss in detail the mechanism by which HR operates to maintain genome stability as revealed by studies predominantly performed in Saccharomyces cerevisiae. We will then discuss the similarities and dissimilarities between yeast and humans while emphasizing the importance of HR in suppressing carcinogenesis and as a potential therapeutic target.

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Average
Average
Average
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