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A central challenge of gene expression analysis during the last few decades has been the characterization of the expression patterns experimentally and theoretically. Modern techniques on single-cell and -molecule resolution reveal that transcriptions and translations are stochastic in time and that clonal population of cells displays heterogeneity in the abundance of a given RNA and protein per cell. Hence, to take into account a cell-to-cell variability, we consider a stochastic model of transcription and the chemical master equation. Our stochastic analysis and Monte-Carlo simulation show that the limiting distribution of mRNA copy number can be expressed by a Poisson-beta distribution. The distribution represents the four different types of expression patters, which are typically found in various experimental profiles.
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 1 | |
popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Average | |
influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Average | |
impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Average |