That research in the trichothecene field is an area of intense interest cannot be disputed. In the years 1982 and 1983, there were more than 500 publications dealing with this subject, including more than 30 reviews. In addition, a comprehensive monograph has recently appeared (151). Virtually every aspect of the problem has been reviewed, including isolation and structure determination (8, 9, 70, 75, 81, 136), biological and biochemical studies (11, 39, 136, 155), toxicology (110, 154, 156), quantitative methods for determination (7, 108, 126, 153), and biosynthesis (35, 137). Efforts directed at the chemical synthesis of trichothecenes have received less attention (47, 112, 138, 141), primarily due to the relative scarcity of published material on the topic prior to 1980. However, since that time, more than ten total syntheses of naturally occuring trichothecenes have been reported, including some of the structurally more complex members of the family. The data base Federal Research in Progress reveals that for fiscal year 1982, there were nine research groups with U.S. government funding pursuing the chemical synthesis of trichothecenes. In light of this proliferation of synthetic work, the present review will concentrate on that area. One deviation from this plan will be an exhaustive compilation of known naturally occurring compounds with trichothecenoid structures. This listing will be an update of an earlier tabulation by Tamm (137) and will generally follow Tamm’s previous format.