We demonstrated that nerve growth factor (NGF) levels were increased in hippocampus and cortical areas, as well as in cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD). Such increases may, at least in part, be due to a decreased expression of the NGF high affinity receptor trkA. Measurement of CSF levels of NGF may add to the repertoire of potential biochemical diagnostic markers in living AD patients.

Related Organizations

National Cerebral and Cardiovascular Center
Japan
Duke Medical Center
United States
Duke University
United States
University of Zurich
Switzerland
University of Basel
Switzerland

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Keywords

Cerebral Cortex, Alzheimer Disease, Parietal Lobe, Humans, Nerve Growth Factors, Receptors, Nerve Growth Factor, Receptor, trkA, Hippocampus

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