When Gottlieb Haberlandt started culturing isolated plant cells in artificial nutrient media he was mainly interested in cell to cell relationships within complex multicellular organisms. Discussing the results of his experiments he pointed out that inspite of remarkable cell growth, cell division was never observed (Haberlandt 1902). He speculated that “growth enzymes” obviously were necessary for stimulating cell division, and he recommended the addition of extracts from meristem tissue (“Vegetationsspitzen”) to the nutrient solutions. He stressed as well the use of embryo sac fluid. Haberlandt expected that the method of cultivating isolated plant cells would permit investigations of important problems from a new experimental approach. At that time he did not consider that cell culture could be useful for commercial propagation of plants.