The hepatitis B virus X protein transactivation of c-fos and c-myc proto-oncogenes is mediated by multiple transcription factors
The hepatitis B virus X protein transactivation of c-fos and c-myc proto-oncogenes is mediated by multiple transcription factors
We have constructed two expression vectors in order to study the action of the HBV 17 Kd X protein on the c-fos and c-myc promoters. The results show that the promoters contain multiple elements that respond to X protein, suggesting involvement of multiple transcription factors. The exact mechanism of the interaction remains elusive, but our data allow speculation about the factors that may be influenced.
- University of L'Aquila Italy
- Max Planck Society Germany
- Policlinico Umberto I Italy
- Max Planck Institute of Biochemistry Germany
- Institut Pasteur France
Chloramphenicol O-Acetyltransferase, Transcriptional Activation, Hepatitis B virus, Recombinant Fusion Proteins, DNA Mutational Analysis, Genetic Vectors, Genes, myc, Genes, fos, Promoter Regions, Genetic, Transcription Factors
Chloramphenicol O-Acetyltransferase, Transcriptional Activation, Hepatitis B virus, Recombinant Fusion Proteins, DNA Mutational Analysis, Genetic Vectors, Genes, myc, Genes, fos, Promoter Regions, Genetic, Transcription Factors
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