The prevalence of invasive fungal infections has risen significantly worldwide, and although over 600 fungal species are reported as human pathogens, Candida species are arguably the most frequently isolated and the most important cause of morbidity and mortality in humans. In fact, Candida species are considered the fourth most common cause of hospital-acquired bloodstream infections in the United States. Candida albicans is the principal candidal pathogen; however, infections caused by non-C. albicans (NCAC) species, such as C. glabrata, C. dubliniensis, C. tropicalis, and C. parapsilosis have increased considerably. This changing dynamic in NCAC species has been suggested to be due to their intrinsic resistance toward antifungal drugs when compared with C. albicans.