Nitric Oxide Synthases

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Other literature type 01 Jan 1996Publisher:Springer Berlin Heidelberg

Authors: Yuri F. Belyi;

doi: 10.1007/978-3-662-22047-4_6

Nitric Oxide Synthases

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Abstract

Nitric oxide (NO) is a biologically active product enzymatically formed from a terminal guanidino-nitrogen of L-arginine by members of the NO synthase (NOS) gene family. Members of NO synthases are classified into three isoforms NOS 1, 2, and 3. This original classification of NOS was based on the physical and biochemical characteristics of the purified enzymes, i.e., subcellular location (soluble vs. particulate fraction), regulation by free Ca2+ concentrations and inhibition by specific inhibitors.336

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