Biosynthesis of O-Glycans

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Other literature type 01 Jan 1997Publisher:Springer Berlin Heidelberg

Authors: Inka Brockhausen; William Kuhns;

doi: 10.1007/978-3-662-21960-7_4 , 10.1007/978-3-662-21960-7_6

Biosynthesis of O-Glycans

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Abstract

The initial steps in the biosynthesis of N-glycans have been are preserved throughout evolution and are similar in lower and higher species. In contrast to O-glycans, N-glycans are pre-assembled as a dolicholpyrophosphate-(Dol-P-P-) intermediate and then transferred to protein by the action of oligosaccharyltransferase in the ER. Subsequent processing includes the trimming of Glc and Man residues and the addition of various sugars by Golgi glycosyltransferases (Fig. 3).

Related Organizations

University of Toronto
Canada
Hospital for Sick Children
Canada

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