Virus-Neuron-Cytotoxic T Lymphocyte Interactions
Virus-Neuron-Cytotoxic T Lymphocyte Interactions
Neurons have evolved unique strategies to evade immune recognition which allow viruses to infect and persist, yet resist attack by antiviral cytotoxic T lymphocytes (CTLs). However, the ability of activated CTLs to percolate through the normal central nervous system (CNS) (Hickey et al. 1991), coupled with focal upregulation of immune regulatory proteins on resident CNS cells in response to CNS insults (Canella et al. 1990), has suggested that the immune response can serve either in the resolution of viral infections of the CNS or in the precipitation of CNS disease.
- Scripps Research Institute United States
Central Nervous System, Neurons, Antigen Presentation, H-2 Antigens, Mice, Inbred Strains, Cell Communication, Immunotherapy, Adoptive, Models, Biological, Animals, Genetically Modified, Mice, Blood-Brain Barrier, Cell Movement, Organ Specificity, Animals, Humans, Lymphocytic choriomeningitis virus, Viremia, Antigens, Viral, Immunologic Memory, T-Lymphocytes, Cytotoxic
Central Nervous System, Neurons, Antigen Presentation, H-2 Antigens, Mice, Inbred Strains, Cell Communication, Immunotherapy, Adoptive, Models, Biological, Animals, Genetically Modified, Mice, Blood-Brain Barrier, Cell Movement, Organ Specificity, Animals, Humans, Lymphocytic choriomeningitis virus, Viremia, Antigens, Viral, Immunologic Memory, T-Lymphocytes, Cytotoxic
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