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Autoimmunity and Chagas’ Disease

Authors: L. Hudson; G. B. Takle;

Autoimmunity and Chagas’ Disease

Abstract

The protozoan flagellate Trypanosoma cruzi is the causative agent of Chagas’ disease and has been estimated to infect between 10 and 12 million people in Central and South America (WHO 1960). T. cruzi has a complex life cycle involving stages in both a vertebrate and an insect vector host, the reduviid or assassin bugs, members of the subfamily Triatominae. Transmission of infective metacyclic trypomastigotes to the vertebrate host occurs following feeding and defecation by the bug and contamination of a wound site or penetration of nearby mucous membranes by the parasite. T. cruzi is thus placed in the class Stercoraria in contrast to the pathogenic African trypanosome species, which are Salivaria, whose transmission to the vertebrate occurs by inoculation via the insect’s salivary glands.

Keywords

Trypanosoma cruzi, Animals, Humans, Antigens, Protozoan, Autoimmunity, Chagas Disease, Laminin, Cross Reactions

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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    30
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
Powered by OpenAIRE graph
Found an issue? Give us feedback
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
30
Average
Top 10%
Top 10%
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