Cyclin-Dependent Kinase Inhibitors and Human Cancer

As tumor suppressor candidates, cyclin-dependent kinase (CDK) inhibitors have a simple, aesthetic quality. They act directly on the mechanism that drives cells through mitosis and DNA replication. Elimination of CDK inhibitor activity, by mutation for instance, should release CDKs from this form of regulation and remove one of the restraints on cell growth.

Related Organizations

Myriad Genetics (Germany)
Germany

Keywords

Neoplasms, Animals, Humans, Enzyme Inhibitors, Models, Theoretical, Cyclin-Dependent Kinase Inhibitor p16, Cyclin-Dependent Kinases, Germ-Line Mutation

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