Pharmacokinetics of Vasodilating Agents

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Other literature type 01 Jan 1986 English Publisher:Springer Berlin Heidelberg

Authors: Wulf-Dirk Bussmann;

doi: 10.1007/978-3-642-61627-3_12

Pharmacokinetics of Vasodilating Agents

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Abstract

Studies on the metabolism of nitroglycerin in various animal species have shown distinct differences making it problematic to extrapolate from experimental animal data to humans. Needleman et al. (1972) found complete inactivation of nitrates following oral administration in rats as a result of the first-pass effect in the liver.

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Goethe University Frankfurt
Germany

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